The unique and wonderful acoustics of the Church Sanctuary, and the special emphasis that this congregation puts on music, mean that many special musical events are held in this church.

Napa Valley Chamber Music has held many of their season concerts in the First UMC Sanctuary. There are also special concerts and recitals by guest artists held here. The Napa Valley Chorale often performs their holiday concert in this venue.

The church choirs usually have annual concerts and sometimes also appear in other locations in Napa Valley and elsewhere. The Cathedral Choir traditionally holds a concert at Monte La Salle on Palm Sunday afternoon.

Several Christmas Eve services are scheduled to meet a variety of needs: an early service at 4:30 p.m. especially geared to children; a service at 7:30 p.m. that involves the participation of youth; and a candlelight service with anthems and sermon at 11:00 p.m. Special worship services for Ash Wednesday and Maundy Thursday are also traditional.